Endocrinology, Diabetes and Metabolism

Endocrinology, Diabetes and Metabolism 



Thyroid

The Mayo Clinic Thyroid Core Group is composed of endocrinologists, clinical researchers, basic researchers, and individuals involved in the related fields of Nuclear and Laboratory Medicine. Although the group has clinical expertise in all areas of thyroid and eye disease. We have more than 35 on-going IRB-approved research protocols. Our work is supported by several NIH grants, as well as by pharmaceutical and internal Mayo Clinic grants.

Within the area of thyroid cancer, our basic research group is interested in oncogenes, tumor suppressor genes, and the identification of other genes involved in the initiation or spread of malignancy. In addition, studies of novel approaches to therapy of thyroid and other endocrine and non-endocrine cancers using targeted gene therapy are underway. Our group is especially interested in the sodium-iodide symporter as a gene that might have utility in this regard. For clinical study purposes, we have assembled a computerized database of information regarding 3,000 patients with thyroid cancer who have been treated at Mayo since 1940. Analysis of this information is ongoing and has been used for the identification of high-risk groups, establishment of useful prognostic scoring systems, and studies of the impact of primary management on patient outcome. Current clinical studies relate to the role of percutaneous ethanol injection (PEI) in the ablation of cervical node metastasis in selected patients with 131I-resistant disease, the more selective use of 131I in postoperative remnant ablation, the use of recombinant thyrotropin in diagnosis, and treatment of differentiated thyroid cancer, the utility of post-treatment scans in thyroglobulin-positive, diagnostic scan-negative cancers, and the use of FDG PET scanning in thyroid cancer patients.

Our basic studies in the area of Graves' disease involve the immunobiology of the thyrotropin receptor and thyrotropin-receptor autoantibodies, and the pathogenesis and treatment of Graves' ophthalmopathy. Studies are aimed at determining the role of orbital antigens, including the thyrotropin receptor, in initiation and propagation of autoimmune thyroid eye disease. Our group is interested in the relationship between thyrotropin receptor expression and adipogenesis in orbital fibroblasts and the recognition of this antigen by orbital T-cell clones and autoantibodies. We have an ongoing clinical study to determine the utility of long-acting somatostatin for the treatment of Graves' ophthalmopathy. Other areas of clinical interest include the use of orbital radiotherapy or decompression surgery in this condition, the effect of hyperthyroidism on skeletal muscle structure and function, and the treatment and natural history of thyroid dermopathy.
Members

    Rebecca Bahn, M.D., Research Representative
    Michael Brennan, M.D.
    Norman Eberhardt, Ph.D.
    Vahab Fatourechi, M.D.
    Hossein Gharib, M.D.
    Ian Hay, M.D.
    George Klee, M.D.
    Bryan McIver, M.D.
    John Morris, M.D.
    Gregory Wiseman, M.D.

 

Comments

Post a Comment

Popular posts from this blog

Colon cancer

Image
Colon cancer is cancer of the large intestine (colon), which is the final part of your digestive tract. Most cases of colon cancer begin as small, noncancerous (benign) clumps of cells called adenomatous polyps. Over time some of these polyps can become colon cancers. Polyps may be small and produce few, if any, symptoms. For this reason, doctors recommend regular screening tests to help prevent colon cancer by identifying and removing polyps before they turn into cancer. Symptoms Signs and symptoms of colon cancer include: A change in your bowel habits, including diarrhea or constipation or a change in the consistency of your stool, that lasts longer than four weeks Rectal bleeding or blood in your stool Persistent abdominal discomfort, such as cramps, gas or pain A feeling that your bowel doesn't empty completely Weakness or fatigue Unexplained weight loss Many people with colon cancer experience no symptoms in the early stages...
Read more

Dolonex DT Tablet

Image
Dolonex DT Tablet  is a mitigating drug used to diminish irritation in joint pain patients. It likewise assists with joint agony, redness and swelling, spondylitis, Gout and so on. It contains Piroxicam 20 mg which is a NSAID (non-steroidal mitigating drug) that diminishes irritation.  Dolonex DT Tablet is for the most part used to regard irritation in Arthritis as it is a NSAID yet there are a few different uses where it could be taken:- Joint pain Spondylitis Joint Pain Gout Postoperative Pain Rheumatoid Arthritis Osteoarthritis Redness Swelling This is a non-thorough rundown and there may be different utilizations and advantages of the Dolonex DT Tablet too. Kindly don't take this medication since somebody has taken it with comparable manifestations. It would be ideal if you counsel a doctor or a master before utilizing the medication. Dolonex DT Tablet: Side Effects Aside from the employments of Dolonex DT Tablet, there could be sure symptoms related with the medication. I...
Read more

Advantage of Vitamin K2

Image
 Advantage of Vitamin K2    Vitamin K2 or menaquinone is a basic vitamin that many individuals never know about until the point that they have their first kid and the medical caretaker controls a Vitamin K infusion. Tragically, this basic supplement is frequently ignored, and it is vital at all life stages, not only for infants or pregnant mothers. Different vitamins and minerals like Vitamin D, Magnesium and Calcium get the consideration they merit, however K2 is regularly overlooked with critical results. What is Vitamin K2 or menaquinone ? Vitamin K is a fat dissolvable vitamin that is vital for blood thickening and that adds to a sound heart, bones and insusceptible framework. There are a few distinct structures, mostly K1 and K2, however they act diversely in the body: Vitamin K1– (or phylloquinone) is characteristic frame found in greens and vex that is utilized by the liver for appropriate blood coagulating. Vitamin K2– (or menaquinone) is a more absorbable ty...
Read more